About Adipose Tissue Stem Cell Therapy

Adipose tissue, colloquially known as fat, is a loose connective structural tissue that provides insulation, nutrient storage, organ protection (padding) and regulates hormone activity. It is also a rich source of cells that have regenerative abilities such as vascular (endothelial and perivascular cells) and stem cells (adipose-derived and mesenchymal stem cells). Access to these cells can be achieved by clustering of the adipose tissue into small fragments to maintain its native tissue structure by using mild mechanical separation*. The microfragmented fat can be injected into the affected joints where it interacts with your body to orchestrate healing responses that reduce inflammation, facilitate repair and replace damaged tissues. 

The use of microfragmented adipose tissue (MFAT) in treating joint osteoarthritis has been reported in several clinical studies and shows promising results. These studies show that patients with knee osteoarthritis receiving a single injection of MFAT reported a 40%-90% improvement in OA associated symptoms compared to pretreatment.  The reduction in pain was also associated with a significant improvement in knee function with lasting effects up to a year [1-2].

Axiom Regenerative Therapies uses state-of-the-art technologies of currently marketed adipose-derived regenerative therapies.  Such technologies rely on a closed loop system to retain the physiological characteristics of the structural tissue and cells whilst minimising human manipulation to prevent infections. 

*Use of adipose stem cells or stromal vascular fraction from enzymatic digestion of adipose tissue is considered to be an experimental drug and currently it is not an approved regenerative therapy by the FDA.

[1] Cattaneo, G., De Caro, A., Napoli, F., Chiapale, D., Trada, P., & Camera, A. (2018). Micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with symptomatic knee osteoarthritis. BMC Musculoskelet Disord, 19(1), 176. doi:10.1186/s12891-018-2105-8
[2]Hudetz, D., Boric, I., Rod, E., Jelec, Z., Radic, A., Vrdoljak, T., et al. Primorac, D. (2017). The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis. Genes (Basel), 8(10). doi:10.3390/genes8100270

How It Works

1

Extraction

Lipoaspiration is a method commonly used for collecting adipose tissue (fat) during cosmetic procedures with minimal patient complications.

2

Preparation

The harvested adipose tissue is resized into clusters (microfragmentation) and processed through a series of washes using a closed-loop, sterile system that minimizes the risk of infection, inflammation and presence of impurities.

3

Activation

The microfragmented adipose tissue is injected into the affected joint where the cells within the adipose clusters activate anti-inflammatory responses and interact with your body to orchestrate the healing responses that reduce inflammation, facilitate repair and replace damaged tissues.

4

Relief

Some patients experience pain relief shortly after their treatment. Significant pain relief is normally felt after two weeks, and the healing process continues with full benefits experienced after six to eight weeks.

Stem Cells can Treat:

  • Spinal injuries, neck pain and back pain
  • Knee, hip and shoulder pain
  • Elbow, hand, wrist and foot pain
  • Soft tissue injury (Tennis Elbow, Plantar Fasciitis)