About ALPHA2ACTIVE™ Therapy

Alpha-2-Macroglobulin (A2M) is a naturally-occurring molecule found in your blood.  It acts as a powerful protector against cartilage breakdown by inhibiting the actions of proteins that damage joints and can cause inflammation. Similar to a Venus Flytrap, A2M captures these destructive elements in its two binding sites and eliminates them through your body's natural processes. While the A2M molecule is our body's own defense mechanism, it is unable to enter the joint or disc space in large enough quantities due to it's complex structure. As a result, it is necessary to inject additional concentrated A2M into the affected area to help restore balance and possibly relieve pain.

Through a patented and proprietary process, ALPHA2ACTIVE™ isolates and concentrates A2M from your blood for reinjection at the injury site. The concentrated does helps boost natural healing and support tissue restoration. 

A simple test performed by your doctor can help determine if you are a good candidate for ALPHA2ACTIVE™ therapy. Research has identified "pain protein" as FAC (Fibronectin-Aggrecan Complex) and it's association with painful inflammation. The diagnostic, called FACT (Fibronectin-Aggrecan Complex Test), looks for this unique biomarker in your joint or disc space to indicate the presence of destructive enzymes ALPHA2ACTIVE™ is known to remove.

Early treatment usually equals better recovery. Learn more about ALPHA2ACTIVE™ and your joint health.

How it Works



During an in-office visit, a blood sample is drawn and run through a centrifuge to separate it's components.



The solution is filtered through a proprietary system to isolate the A2M molecules for a concentrated dose.



The optimal solution is injection into your injury site to begin baiting and trapping the destructive proteins known to cause inflammation.



Some patients begin experiencing pain relief shortly after their first injection. The healing process continues and individual results may vary. The number of treatments is determined by your doctor and care plan.

ALPHA2ACTIVE™ has been used by physicians in the following applications:

  • Osteoarthritis
  • Bursitis
  • Ligament sprains and tears
  • Tendonitis and tendinosis
  • Plantar fasciitis
  • Tennis or Golfer’s Elbow
  • Degenerative disc or joint disease

Related Research


Identification of 2-Macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis

Objective. To determine if supplemental intraarticular 2-macroglobulin (2M) has a chondroprotective effect in a rat model of osteoarthritis (OA).

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A Dose Response Analysis Of A Specific Bone Marrow Concentrate Treatment Protocol For Knee Osteoarthritis

Prior studies describing the treatment of symptomatic knee osteoarthritis with injections of bone marrow concentrate have provided encouraging results. The relationship between the cellular dose contained within the bone marrow concentrate and efficacy of the treatment, however, is unclear. In the present study we describe clinical outcomes for symptomatic knee osteoarthritis in relation to higher and lower cell concentrations contained within a bone marrow concentrate treatment protocol.

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How Regenerative Medicine is Used To Treat Sports Injuries

If you have a sports injury that hasn’t healed from physical therapy or rest, regenerative medicine could be an option for you. Regenerative medicine treatments use functional tissues to repair or replace tissue or organ function loss due to age or damage. For sports injuries specifically, the goal is to reduce pain and improve function. Treatments include stem cell therapy, platelet rich plasma (PRP), prolotherapy, certain cartilage regeneration procedures and more.

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